Consanguinity Test
This test analyses an individual's genome file to identify “Runs of Homozygosity” (ROH), which are stretches of identical genetic sequences inherited from both parents. Longer and more frequent ROH indicate that the parents share a recent common ancestor, suggesting they are closely related.
Discover - “Are your parents related?”
Even if you do not have access to their genome files, the Consanguinity Test can detect and define that information, using only your genome file.
Why closely related parents are not ideal
Having closely related parents increases the likelihood of inheriting harmful recessive genetic variants, which can lead to health issues. Studies have shown that high parental relatedness is associated with increased risks of genetic disorders and reduced genetic diversity.
Optimal Genetic Distance
Research, including a study from Iceland, suggests that reproduction between individuals at a genetic distance of 3rd to 7th cousins is ideal.
This balance maximises genetic diversity while preserving beneficial traits within an ethnic group.
The Icelandic study, conducted by deCODE Genetics, is one of the most comprehensive genetic research projects ever undertaken.
Researchers sequenced the genomes of 2,636 Icelanders and analysed genetic data from over 100,000 others, leveraging Iceland's detailed genealogical records,
which trace back over 1,000 years. This homogeneity allowed scientists to identify 20 million genetic variants and study their role in human health and evolution.
One key finding from this research was related to genetic relationships and reproduction. The study revealed that while close genetic relationships between
parents (e.g., first cousins) can lead to increased risks of genetic disorders due to reduced genetic diversity, reproduction between individuals
at an optimal genetic distance—approximately 3rd to 7th cousin level—maximizes fertility and offspring health.
This balance preserves beneficial traits while minimizing harmful recessive mutations.
Reference study: https://pubmed.ncbi.nlm.nih.gov/18258915/